“Flow chemistry,” also called “continuous flow chemistry” or “plug flow chemistry,” is used to describe a range of chemical reactions that occur in a continuously flowing stream as contrasted to classic static batch reactor systems. What the two have in common is the ‘reaction time’. The chemical industry has used flow chemistry systems for decades due to their speed, repeatability, inventory control and scalability. What is new is the ability to perform multiple and repeatable flow chemistry reactions on an automated platform, rapidly with very low volumes.
For continuous flow reactions, especially multi-stage continuous flow reactions, the formation of solids has always been a big problem. In the existing standardized microreactors, the solid particles produced by the reaction are very easy to accumulate at the back pressure valve and the corners of the reaction pipeline and eventually cause the pipeline to block.
There are many influencing factors in the chemical reaction process, including temperature, pressure, flow rate, raw material concentration, material ratio, feeding sequence, residence time, etc., and the various factors are interrelated and mutually restricted. Therefore, in the face of a given result in the experiment, such as the incomplete reaction of the raw materials, one should not only consider its direct influence factors, such as whether the residence time is insufficient, but should be grasped from a macro perspective, in order to understand the context of the entire reaction and the various influences. After the relationship between the factors, it can be solved by increasing the reaction temperature, increasing the concentration of the reactant, reducing the material flow, or increasing the coil or reaction plate.