Small-scale continuous flow microchannel reactor

Small-scale continuous flow microchannel reactor

The use of micro-reaction continuous flow technology can save land and personnel costs. The new technology has a high degree of automation, greater process controllability, safer production, high production efficiency, low operating costs, and guaranteed product quality. The use of new technology can promote the rapid upgrading of domestic technology and enhance the product's position in the international market. The scope and field of continuous flow synthesis continue to expand, not only including traditional reaction types and the pharmaceutical and fine chemical industries, but also extending to the fields of electrochemistry, photochemistry, microwave chemistry, nanomaterials, and functional materials.


The glass continuous flow microchannel reactor MF-V6 is compatible with all reagents except hot concentrated strong alkali, molten alkali metal, hot concentrated H3PO4, HF, and strong corrosive agents. It can operate stably for a long time. The excellent high light transmittance can realize short wavelength range. The photocatalytic reaction.


In addition, due to the light transmittance of glass, glass microreactors are better than microreactors made of other materials in the direction of photocatalysis.


MF-V6 (9ml) is the maximum liquid holding capacity of the monolithic microreactor, thereby prolonging the reaction residence time of the monolithic microreactor. Under the conditions of the same flow rate, the larger the liquid holding capacity of the monolithic microreactor, the longer the residence time of the reaction phase in the microreactor, and the more ideal the reaction effect can be achieved for some reactions that require reaction time. This product can also be customized for other models with different specifications of liquid holding capacity, 9ml is the maximum processing depth. The annual throughput can reach 70T/year, which can also meet the needs of small-scale experiments and production.


This product is suitable for various chemical reactions and mixing processes, especially for the formation of nanoparticles. It has certain solid compatibility and can produce nanoparticles continuously and stably. It can be used in pharmaceutical intermediates, drug synthesis (including outsourcing), fine chemicals, pesticide chemicals, special chemicals, daily necessities industry, nanomaterials, polymer modification and other fields.


This set of device can connect 2-8 sets of independent chips in series to form a system, which greatly extends the residence time of the sample and improves the yield.


Small-scale high-throughput continuous flow microchannel reactors have been used in some cases, including nitration reaction, strong exothermic reaction, low-temperature Friedel-Crafts reaction, gas-liquid reaction, Michael addition reaction, Friedel-Crafts alkylation reaction, aldol Condensation reaction (sodium ethoxide), sulfonation reaction, nitration reaction, diazotization reaction, azide reaction, solvent-free reaction, etc.



Application field

· Photochlorination


· Production of Vitamin D


· Photoalkylation


· Production of artemisinin (anti-malaria drug)


· Production of Caprolactam


Basic parameters:


Model: MF-V6


Material: high borosilicate glass


Flux: 80T/year


Pressure resistance: 25Bar


Temperature resistance: -60-230℃


 



Chemical synthesis reaction has become a hot spot in the research of modern API production technology due to its advantages such as the use of clean energy, high energy utilization, high selectivity, high atom economy, and mild and controllable reaction conditions. In particular, photochemistry has become a chemistry in the past decade. A powerful tool in the field of synthesis. Although the improvement of LED technology has introduced high-efficiency monochromatic light sources, it is more conducive to photochemical reactions. However, the poor light distribution inside the intermittent kettle will lead to prolonged reaction time and excessive light to form by-products. This problem is more likely to occur during the amplification process. Continuous flow technology has been proven to be an effective method to solve this problem because of the narrowness. The reaction channel can ensure uniform light irradiation and improve heat and mass transfer effects.


At present, the main obstacle to large-scale commercial production of mobile photochemistry is the problem of amplification effect. Although the process expansion can be achieved relatively easily by digital amplification, in order to achieve the corresponding production scale, it is usually not enough to rely solely on the digital amplification method. The choice of photochemical reactor requires a high level of reactor engineering technology and expertise in scale-up, because as the size of the reactor increases, maintaining consistent luminous flux is a huge challenge. A photochemical reactor with efficient mass and heat transfer and no amplification effect can help customers achieve effective amplification.


The microchannel photochemical reactor has the characteristics of high light transmittance, high temperature resistance, high pressure resistance, high light intensity, pure light source, precise temperature control, and no amplification effect. It has unique technical advantages and wide application prospects in photochemical reactions.


In addition, the photochemical reactor can be combined with on-line NMR (nuclear magnetic resonance) to quickly screen the reaction process parameters, effectively improving the process of new molecule exploration and process optimization.


In the past ten years, reports of photochemical reactions have increased exponentially. Catalysis by photo-redox catalysts or catalytic systems that combine photosensitizers with transition metal catalysts and organic molecular catalysts has become a powerful method for building chemical bonds. Since the photochemical reaction can be realized by using visible light, ultraviolet light or cheap LED lights, the photochemical reaction has been widely used in academia and industry.


Although tremendous progress has been made in photochemical reactions, it is undeniable that there are still some limitations in the operation of such reactions. According to the Lambert-Beer law, in the reaction medium, the photon flux decreases exponentially with the depth of the solution, so only the liquid with a thickness of 2 mm close to the tube wall can be effectively illuminated. In traditional photochemical reactions, there have been two problems: (1) low photon penetration related to the width of the tube wall; (2) reduced photon capture caused by low surface area exposure.


In order to solve the above-mentioned problems, people naturally think that the intensity of light can be increased to improve the reaction effect, and experiments are carried out by moving the light source closer to the reaction vessel and increasing the number of light sources. However, this strategy often causes an increase in thermodynamic side reactions, which leads to a decrease in reaction yield. Another method is to introduce a cooling system, but it will make the operation cumbersome and in most cases the response cannot be improved. The distance between the reaction vessel of the photochemical reaction and the light source and the type, geometry and distance of the light source can significantly affect the efficiency of the reaction.


   Based on Newton's law of cooling, the light irradiation energy is measured and calculated, the light source and distance are determined, and a suitable lighting system is designed



Photochemical reactions in organic synthesis

Barton nitrite photolysis reaction


Barton radical decarboxylation


Bergman aromatic cyclization reaction


Brandi-Guama spirocyclopropane rearrangement reaction


Büchner ring expansion reaction


Curtius rearrangement


de Mayo Reaction (de Mayo Reaction)


Dimroth rearrangement reaction


Di-π-methane Rearrangement


Feldman alkene cyclopentane synthesis reaction


Fries rearrangement


Nazarov cyclization reaction


Paternó–Büchi reaction


Reimer--Tiemann reaction


Vinylcyclopropane-cyclopentene rearrangement (alkenyl cyclopropane-cyclopentene rearrangement)


Wolff rearrangement


Wohl--Ziegler reaction


Study on the benzene ring-closure reaction of N-phosphonoalkynamine and α-diazoketone through a flow reactor under photocatalysis


Visible light/Ni dual-catalyzed cross-coupling reaction of secondary alkyl and aryl groups


Ciamician--Dennstedt rearrangement


Decarboxylative Coupling


Basic parameters:


Model: MF-V6


Material: high borosilicate glass


Flux: 80T/year


Pressure resistance: 25Bar


Temperature resistance: -60-230℃


This product is suitable for various chemical reactions and mixing processes, especially for the formation of nanoparticles. It has certain solid compatibility and can produce nanoparticles continuously and stably. It can be used in pharmaceutical intermediates, drug synthesis (including outsourcing), fine chemicals, pesticide chemicals, special chemicals, daily necessities industry, nanomaterials, polymer modification and other fields.


Small-scale high-throughput continuous flow microchannel reactors have been used in some cases, including nitration reaction, strong exothermic reaction, low-temperature Friedel-Crafts reaction, gas-liquid reaction, Michael addition reaction, Friedel-Crafts alkylation reaction, aldol Condensation reaction (sodium ethoxide), sulfonation reaction, nitration reaction, diazotization reaction, azide reaction, solvent-free reaction, etc.


Application field

· Photochlorination


· Production of Vitamin D


· Photoalkylation


· Production of artemisinin (anti-malaria drug)


· Production of Caprolactam