Glass Microreactors

MF-V6 Kilo-scale glass flow reactors

MF-V6 Kilo-scale Glass Microchannel Reactor Features:Available in integrated multilayer glass construction for mixing, reaction & heat transfer;Micro channel with modular system to connect multiple reactors in series or parallel;Suitable for various liquid-liquid, gas-liquid homogeneous & multi phase reactions;Useful in photochemical & UV induced reactions

  • Temperature range: -25°C-200°C
  • Pressure tolerance: ≤20bar
  • Flow rate: 0-100mL/min
  • Flexible volume: 3~9ml
  • Summary: MF-V6 small-scale glass continuous flow reactors have integrated pre-heat & heat exchange giving optimal thermal control for challenging flow chemistry applications. V6 flow reactor system (flow reactor used in combination with pumps, heat exchangers, temperature control and pressure regulation) that is designed to readily access extreme temperatures (-25 °C to 200 °C), reaction times and pressure conditions (up to 20 bar). V6 enables previously ‘forbidden’ transformations to be executed within a conventional laboratory, and is ideal for up-scaling with no change in mixing efficiency.

MF-V6 is a glass Flow Reactor for process development & small-scale production.  With integrated heat exchange, V6 is suitable for performing challenging chemistries & processing conditions. Fabricated from borosilicate glass, the Flow Reactor modules have integrated heat exchange layers that allows thermal regulation of feeds & mixing, enabling control of heat of reaction!

MF-V6 is a pilot flow reactor system (flow reactor used in combination with pumps, heat exchangers, temperature control and pressure regulation) that is designed to readily access extreme temperatures (-25 °C to 200 °C), reaction times and pressure conditions (up to 20 bar). KiloFlow enables previously ‘forbidden’ transformations to be executed within a conventional laboratory, and is ideal for up-scaling with no change in mixing efficiency.

The MF-V6 glass continuous flow reactors is a high-throughput glass microreactor processed from high borosilicate float glass. The four-layer structure design includes the heat exchanger in the reactor to reduce the space occupancy rate. The design of the structure ensures the maximization of mixing efficiency, so that the reaction phase forms multiple vortex staggered states in the reaction phase, and ensures that the reaction phase is fully mixed and reacted in the flow channel.

The MF-V6 series glass microchannel reactor is compatible with all reagents except hot concentrated alkali, molten alkali metal, hot concentrated H3PO4, HF, and strong corrosive agents. It can operate stably for a long time. The excellent high light transmittance can achieve short wavelength Photocatalytic reaction. Compared with the traditional tubular catalysis, the microreactor can also increase the catalysis conditions and promote the formation of reactants through the application of the heat exchange layer.

MF-V6 (9ml) is the maximum liquid holding capacity of the monolithic continuous flow microreactor, thereby prolonging the reaction residence time of the microchannel reactor. Under the conditions of the same flow rate, the larger the liquid holding capacity of the micro-channel reactor, the longer the residence time of the reaction phase in the microreactor, and the more ideal the reaction effect can be achieved for some reactions that require reaction time. This product can also be customized for other models with different specifications of liquid holding capacity, 9ml is the maximum processing depth. The annual throughput can reach 70-80T/year, which can also meet the needs of small-scale experiments and production.

Brochure

Salient features of MF-V6 glass flow reactors

· Available in integrated multilayer glass construction for mixing, reaction & heat transfer

· Micro channel with modular system to connect multiple reactors in series or parallel

· Suitable for various liquid-liquid, gas-liquid homogeneous & multi phase reactions

· Useful in photochemical & UV induced reactions

· Specially designed micro reactors from Microflu™ microchannel reactors used in various photochemical and UV induced reactions.

· Compatible with all reagents except hot concentrated alkali, molten alkali metal, hot concentrated H3PO4, HF, and strong corrosive agent, it can run stably for a long time.

Reaction type(Technological Process)

The free combination modular system configuration can connect multiple reactors in series or in parallel to realize one-step and multi-step synthesis reactions. The highly flexible modular design ensures that it can adapt to the requirements of various processes.

Series: used to delay the residence time and ensure the reaction conversion rate meets the technical requirements.

Parallel connection: used to increase production capacity to ensure that the production demand is guaranteed while the conversion rate is reached.

A+B=C (one-step series connection) A+B=C+Q=D (multi-step series connection) A+B=Q1 C+D=Q2 Q1+Q2=D (multi-step series connection + series connection).

Suitable for type reactions up to A+B=C+Q=D or A+B=C or A+B=Q1 C+D=Q2

MF-V6 kilo-scale glass flow reactors specifications

Flow rate:  0.1-100ml/minup to 6kg/h

Flexible reactor volumes:  3ml or 6ml or 9ml

Wetted materials:  Glass,PFA, PFA & FFKM Or 316L

Dimensions:  152.4x152.4x 11mm

MF-V6 kilo-scale glass flow reactors applications

·  Assessment of process feasibility under flow conditions

·  Exploration of novel reaction space

· Process parameter optimisation & validation

· Rapid kinetic profiling

· Evaluation of parameter influence on CQA's

Specifications of MF-V6 glass flow reactor

MF-V6 Series  Kilo-scale glass flow reactors

Model

MF-V6-M

MFV6-M(6)

MF-V6-M(9)

MF-V6S-M

Size

152.4x152.4x 11mm

Material

Borosilicate Glass

Channel Size

/

Channel Length

1.8m

Volume

3ml

6ml

9ml

9ml

Surface to volume ratio(u)

/

/

/

/

Design temperature (°C)

-25°C-200°CCustom-30℃-280℃

*The difference between the glass temperature and the outside temperature is controlled within 70℃

Design pressure (bar)

≤20bar(Recommended pressure ≤ 1.7Mpa)

Flow rate

0-100mL/min

Features/Advantages

Available in integrated multilayer glass construction for mixing, reaction & heat transfer;

Micro channel with modular system to connect multiple reactors in series or parallel;

Suitable for various liquid-liquid, gas-liquid homogeneous & multi phase reactions;

Useful in photochemical & UV induced reactions;

Process Case

1. Michael addition reaction

2. Friedel-Crafts alkylation reaction

3. Aldol condensation reaction (sodium ethoxide)

4. Sulfonation reaction and nitration reaction

5. Diazotization reaction, azide reaction

6. Solvent-free reaction, 30% liquid-liquid reaction (high probability)


Video demonstration of MF-V6 continuous flow glass microchannel reactor:

MF-V6 Glass Continuous Flow Reaction Systems:

MF-V6 Glass Continuous Flow Reaction Systems

Example Of Applications

The following reactions are done with micromixer or  jet mixer( emulsifier) if 2 phase reaction was carried out.

· Synthesis of semiconducting polymers for OLED applications

· Synthesis of azo dye via azo coupling

·Synthesis of hydroxymethylfurfural (HMF) and furandicarbonacid (FDCA) out of renewable resources

· Synthesis and work up of nitrate ester

· Catalyzed oxidation for synthesis of functional aldehyde

· Synthesis and conversion of diazomethane

· Photochlorination, bromination, alkylation etc.

Casenitration,strong exothermic reaction,friedel-Crafts reaction,gas-liquid reaction

nitration,strong exothermic reaction,friedel-Crafts reaction,gas-liquid reaction

The use of micro-reaction continuous flow technology can save land and personnel costs. The new technology has a high degree of automation, greater process controllability, safer production, high production efficiency, low operating costs, and guaranteed product quality. The use of new technology can promote the rapid upgrading of domestic technology and enhance the product's position in the international market. The scope and field of continuous flow synthesis continue to expand, not only including traditional reaction types and the pharmaceutical and fine chemical industries, but also extending to the fields of electrochemistry, photochemistry, microwave chemistry, nanomaterials, and functional materials.

The glass continuous flow microchannel reactor MF-V6 is compatible with all reagents except hot concentrated strong alkali, molten alkali metal, hot concentrated H3PO4, HF, and strong corrosive agents. It can operate stably for a long time. The excellent high light transmittance can realize short wavelength range. The photocatalytic reaction.

In addition, due to the light transmittance of glass, glass microreactors are better than microreactors made of other materials in the direction of photocatalysis.

Small-scale high-throughput continuous flow microchannel reactors have been used in some cases, including nitration reaction, strong exothermic reaction, low-temperature Friedel-Crafts reaction, gas-liquid reaction, Michael addition reaction, Friedel-Crafts alkylation reaction, aldol Condensation reaction (sodium ethoxide), sulfonation reaction, nitration reaction, diazotization reaction, azide reaction, solvent-free reaction, etc.

Application field

· Photochlorination

· Production of Vitamin D

· Photoalkylation

· Production of artemisinin (anti-malaria drug)

· Production of Caprolactam

MF-V6 continuous flow microreactor Schematic diagram of the continuous production of nanomaterials case process

Product categories: glass reactors, high temperature and high pressure reactors, continuous flow reactors, high flux reactors, small test microchannel reactors, micro reactors, gas-liquid reactors, solid-liquid reactors, photochemical (catalytic) reactors .

Applicable reaction types: liquid-liquid reaction, gas-liquid reaction, compatible partial solid-liquid reaction.