MICROFLU® industrial flow reactors are modular glass reactors for the performance of continuous flow reactions at ton scale. microchannel reactors are suitable for chemically challenging reactions under extreme processing conditions such as fast, highly exothermic reactions, reactions with aggressive media, reactions employing unstable intermediates or hazardous reactions not accessible under batch conditions
MF-V9 is a glass Flow Reactor for manufacturing at the multi-metric tonne-scale. With integrated heat exchange, MF-V9 gives optimal control for the scale-up of challenging chemistries & process intensification at scale.
Production-scale& Tonne-scale Glass Flow Microreactor( Pilot & full-scale production Microchannel Reactor)
MF-V9 is a modular, glass Flow Reactor for process development, pilot & full-scale production. Fabricated from borosilicate glass, with integrated heat exchange, MF-V9 flow reactor modules give unrivalled chemical compatibility & process control for challenging chemical applications at scale.
Employing standard tube fittings, MF-V9 flow reactor can be used with existing pumps & thermostats, or supplied as total systems on request.
MICROFLU® industrial flow reactors are modular glass reactors for the performance of continuous flow reactions at ton scale. microchannel reactors are suitable for chemically challenging reactions under extreme processing conditions such as fast, highly exothermic reactions, reactions with aggressive media, reactions employing unstable intermediates or hazardous reactions not accessible under batch conditions.
MF-V9 is a modular glass Flow Reactor for process development, pilot & full-scale production. With integrated heat exchange, MF-V9 gives optimal control for challenging chemistries & process intensification at scale.
Microreaction technology has established itself as an important technological component in particular in the chemicals and pharmaceuticals industry as well as in process technology. Through the use of microreactors, micromixers and other components in microprocess technology of the kind offered by the Microflu Factory, various advantages in processes of all kinds in the sphere of process technology can be achieved. In the production of fine chemicals and the intensification of chemical processes, microreaction technology is a recognised and efficient approach with a rapidly increasing relevance.
The advantages of microreaction technology using Microflu technology include:
·Rapid mixing effect
·Optimal controllability through low system inertia
·Short delay time
·Precisely adjustable course of the procedure
·Good control of strong exothermic effects
·High operating safety through minimal content
Minimal environmental requirements through small quantities of substances
Microtechnological installation configurations by the Microflu are available for one-step and multi-step systems, for exothermic and low temperature reactions, for the precipitation of particles and solids, and for homogenous as well as heterogenous reactions. The configurations can be expanded through the use or exchange of additional modules and adapted to suit the outcome in question.
When using microreaction technology, significant improvements can be achieved compared with conventional synthesising processes with regard to yield, selectivity, product quality and safety in the case of reactions with a strong heat effect or dosage or mixture-sensitive reactions. Furthermore, microreaction technology also provides access to new synthesis approaches and possibilities of process conduction with the achievement of improved yields as regards both space and time.
· Suitable for mixing of miscible, immiscible liquids & gases
· Very high surface to volume ratio
· Very high heat & mass transfer coefficient
· Screening Tool for Continuous Flow Feasibility Studies
· Easy to clean - Openable design
· Ideal for fast & exothermic reactions
Application of Microchannel Reactor
Mixing of miscible liquids or immiscible liquids or gases creating dispersion of immiscible fluids or gases in liquids and carrying out very fast, exothermic & homogeneous reactions. Some of the tested applications include nitrations, halogenations, sulfoxidation, sulfonation, esterification, diazotization, condensation reactions, halogenations, reduction, oxidation, etc.
· Available in integrated multilayer glass construction for mixing, reaction & heat transfer
· Micro channel with modular system to connect multiple reactors in series or parallel
· Suitable for various liquid-liquid, gas-liquid homogeneous & multi phase reactions
· Microreactors from glass, quartz, silicon and glass-silicon compounds
· Useful in photochemical & UV induced reactions
· Specially designed micro reactors from Microflu microchannel reactors used in various photochemical and UV induced reactions.
MF-V9 is a glass Flow Reactor designed for process development & Midle-scale production. Fabricated from borosilicate glass, the Flow Reactor has integrated heat exchange layers & pre-conditioning channels that allow mixing at the reaction temperature & thermal control of the reaction itself!
MF-V9 is a modular, glass Flow Reactor for pilot & full-scale production. Fabricated from borosilicate glass, with integrated heat exchange, MF-V9 modules give unrivalled chemical compatibility & process control for challenging chemical applications at scale.
The MF-V9(S) thousand-ton glass microreactor has the advantages of large specific surface area, high mass and heat transfer efficiency, high safety, and small amplification effect. Compared with the traditional batch reaction, it is in the process of reaction amplification and optimization. Medium, it has higher reproducibility, stability and efficiency. In addition, the micro-reactor has a low heat buffer demand, a small floor area, and a high degree of automation, which greatly saves manpower and material resources. The microchannel reactor based on microfluidic technology represents the development direction of green chemical industry.
The MF-V9(S) thousand-ton glass microreactor is a capacity upgrade without magnification structure based on the MF-V6(S) small scale glass microreactor. Compared with MF-V6(S), MF-V9(S) does not amplify the former unit hybrid structure to the same proportion, but transfers the unit hybrid structure of MF-V6(S) in parallel with 8 threads without amplification. , Through the special design of 3-layer heat exchange, 2-layer process, and 1-layer sealing, the flux is increased by 15-20 times, and the heat exchange efficiency is further strengthened, so that the reaction can still be obtained in the case of high flux Good heat transfer control. At the same time, the two major factors of mass transfer and pressure drop are taken into account, ensuring mass transfer without amplification effect and small pressure drop, realizing the maximization of mass transfer and heat transfer efficiency, and safely and stably achieving the thousand-ton pilot production process .
MF-V9(s), liquid holding capacity 80ML, 8-pass parallel connection, 6-layer 3 heat exchange 2 process design, flux can reach 1500-2000T/a, support UV light penetration above 315nm UVB (80% light transmittance) , and the same flow pressure.
MF-V9(S) application areas: pharmaceutical intermediates, drug synthesis (including outsourcing), fine chemicals, pesticide chemistry, special chemicals, daily necessities industry, nanoindustry, pharmaceutical preparations, polymer modification, etc.
Nanoparticle liposome preparation and mass production, energetic solid material mass production, pharmaceutical intermediate mass production, nitrification and sulfonation reaction pilot production, etc.
MF-V9(S) has successfully realized process cases:
Mike addition reaction of ethylene glycol and acrylonitrile
Nitration of Acetophenone
Nanoparticle liposome preparation
MF-V9 Glass Continuous Flow Reaction Systems:
Specifications of MF-V9 glass flow reactor
MF-V9 Series Production-scale & Tonne-scale Glass Flow Microreactor
Surface to volume ratio(u)
Design temperature (°C)
*The difference between the glass temperature and the outside temperature is controlled within 70℃
Design pressure (bar)
Available in integrated multilayer glass construction for mixing, reaction & heat transfer;
Micro channel with modular system to connect multiple reactors in series or parallel;
Suitable for various liquid-liquid, gas-liquid homogeneous & multi phase reactions;
*Useful in photochemical & UV induced reactions;
·Mike addition reaction of ethylene glycol and acrylonitrile
·Nitration of Acetophenone
·anoparticle liposome preparation
Examples of User applications:
Fast, strongly exothermic reactions
Reactions with aggressive media & / or unstable intermediates
Material supply under GMP conditions
Processes include nitrations, cyanations, lithiations, diazotisations & halogenations
Suitable for type reactions up to A+B=C+Q=D or A+B=C or A+B=Q1 C+D=Q2
Example Of Applications
The following reactions are done with micromixer or jet mixer( emulsifier) if 2 phase reaction was carried out.
· Synthesis of semiconducting polymers for OLED applications
· Synthesis of azo dye via azo coupling
·Synthesis of hydroxymethylfurfural (HMF) and furandicarbonacid (FDCA) out of renewable resources
· Synthesis and work up of nitrate ester
· Catalyzed oxidation for synthesis of functional aldehyde
The use of micro-reaction continuous flow technology can save land and personnel costs. The new technology has a high degree of automation, greater process controllability, safer production, high production efficiency, low operating costs, and guaranteed product quality. The use of new technology can promote the rapid upgrading of domestic technology and enhance the product's position in the international market. The scope and field of continuous flow synthesis continue to expand, not only including traditional reaction types and the pharmaceutical and fine chemical industries, but also extending to the fields of electrochemistry, photochemistry, microwave chemistry, nanomaterials, and functional materials.
The glass continuous flow microchannel reactor MF-V9 is compatible with all reagents except hot concentrated strong alkali, molten alkali metal, hot concentrated H3PO4, HF, and strong corrosive agents. It can operate stably for a long time. The excellent high light transmittance can realize short wavelength range. The photocatalytic reaction.
In addition, due to the light transmittance of glass, glass microreactors are better than microreactors made of other materials in the direction of photocatalysis.
Small-scale high-throughput continuous flow microchannel reactors have been used in some cases, including nitration reaction, strong exothermic reaction, low-temperature Friedel-Crafts reaction, gas-liquid reaction, Michael addition reaction, Friedel-Crafts alkylation reaction, aldol Condensation reaction (sodium ethoxide), sulfonation reaction, nitration reaction, diazotization reaction, azide reaction, solvent-free reaction, etc.
· Production of Vitamin D
· Production of artemisinin (anti-malaria drug)
· Production of Caprolactam
continuous flow microreactor Schematic diagram of the continuous production of nanomaterials case process
Product categories: glass reactors, high temperature and high pressure reactors, continuous flow reactors, high flux reactors, small test microchannel reactors, micro reactors, gas-liquid reactors, solid-liquid reactors, photochemical (catalytic) reactors .
Please use it within the specified rated pressure range. If the supplied pressure exceeds 16 bar, the microreactor will be damaged or ruptured, resulting in malfunction.
Please use it within the specified rated temperature difference range. If the supplied temperature difference exceeds 50K, the microreactor will be damaged or ruptured, causing malfunctions. This temperature difference includes the temperature difference between the reactor and the environment, the temperature difference between the reactor and the feed liquid, and the temperature difference between the reactor and the heat exchange medium.
When feeding solids, please note that the diameter of the solid particles should be less than 50μm, and the solid content of the reagent should be less than 5%, otherwise the microreactor may be blocked. During the reaction process, it is easy to produce insoluble precipitates (all solvents are insoluble). It is forbidden to carry out in the microreactor, such as the reaction of tert-butyl lithium; at the same time, it is strictly forbidden to freeze any form of internal materials in the reactor (such as water). freeze).
When using the device, do not hit it hard or drop it from a high place. Even if the appearance is not damaged, it may cause malfunction due to damage to the internal parts.
The device is not registered with the FDA and cannot be used as an FDA-certified device in APIs.
Note on temperature difference:
1. When the ambient temperature is room temperature, please use it within the range of 70℃. If you need to work at a temperature above 70℃, please install a protective cover and insulation wool on the outside of the reactor to ensure the difference between the ambient temperature and the temperature of the reactor Less than 50k
2. When the ambient temperature is high, the operation can be carried out without installing a heat shield, because the reactor temperature is consistent with the ambient temperature and there is no temperature difference. (Such as microwave, oven and other heating methods)
3. Regardless of the ambient temperature, the temperature difference between incoming materials and medium must be controlled within 50 k.