Premium API Supply - Ultra-High Purity Crisaborole (99.5%+) – Kilogram-Scale Available
We offer ultra-high purity (≥99.5%) Crisaborole (CAS 906673-24-3) in kilogram (KG) to multi-kilogram scales for global export. Crisaborole is a structurally unique, boron-based non-steroidal molecule that requires exceptional synthesis and purification controls to prevent degradation. Our validated manufacturing process ensures an outstanding impurity profile and strict crystal form consistency. We provide a complete technical documentation package (COA, HPLC, H-NMR, 11B-NMR, MS, MSDS) to fully support global generic pharma developers and topical formulation laboratories specializing in Atopic Dermatitis (AD) treatments.
Chemical Name: Crisaborole (Eucrisa)
CAS Registry Number: [906673-24-3]
Molecular Formula: C₁₄H₁₀BNO₃
Molecular Weight: 251.05
IUPAC Name: 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
Appearance: Off-white to white crystalline powder
Purity (HPLC): ≥ 99.5%
Single Impurity: ≤ 0.1%
Moisture Content: Strictly controlled within pharmacopeia limits
Storage: Store at 2-8°C in a cool, dry, well-ventilated area. Keep container tightly sealed under nitrogen blanketing to protect from moisture, atmospheric humidity, and strong light.
Advanced Impurity Profiling: The synthesis of boron-heterocycle compounds is prone to stubborn critical impurities. Our optimized purification process guarantees a total purity of 99.5% or higher, with individual unknown impurities kept well below ICH guidelines.
Polymorph & Stability Control: We deliver a highly stable crystalline form, ensuring predictable solubility, optimal skin penetration, and uniform blending during your formulation process.
Scalable & Validated Process: Our robust, multi-step synthetic route eliminates reliance on volatile or hazardous raw materials, ensuring long-term batch-to-batch consistency.
Immediate Dispatch Stock: We maintain a continuous, stable inventory of kilogram-scale stock, allowing for rapid shipping to meet tight R&D and pilot-trial timelines.
Enhanced Characterization: In addition to standard HPLC and H-NMR testing, we utilize Boron-11 NMR (¹¹B-NMR) spectroscopy to confirm total molecular structural integrity.
Complete Tech Pack: Every shipment includes a comprehensive Certificate of Analysis (COA), Method of Analysis (MOA), and Material Safety Data Sheet (MSDS). Regulatory support for generic drug filing dossiers is available upon evaluation.
Topical Formulations: Perfect for處方 development of generic non-steroidal anti-inflammatory topical creams, ointments, and gels targeting mild-to-moderate Atopic Dermatitis (Eczema).
Extended Dermatology Research: Investigational pipelines for psoriasis, seborrheic dermatitis, and other skin-barrier inflammatory conditions.
Moisture-Proof Export Packaging: 100g/Aluminum foil bag; 1kg/Aluminum foil bag (lined with double-layer PE bags and sealed under nitrogen gas flushing); 5kg/HDPE drum. Custom specifications are available.
Global Compliant Shipping: Handled by professional, licensed chemical freight forwarders specializing in temperature-and-moisture-sensitive pharmaceutical shipments. We provide complete customs clearance documentation for smooth international transport.
Patent Disclaimer: In absolute compliance with international intellectual property laws, this product is strictly offered for laboratory research, formulation R&D, and generic drug filing purposes (e.g., under Bolar exemptions). No products will be sold or delivered into countries where active commercial product patents are infringed. The buyer bears full responsibility for local patent compliance.