Vanzacaftor（VX-121）

Vanzacaftor（万泽卡托/万扎卡托，VX-121, VX121） 是一种口服有效的新型囊性纤维化跨膜电导 cystic fibrosis transmembrane conductance regulator（CFTR）调节剂，用于改善 CFTR 蛋白加工与细胞膜表面转运。Vanzacaftor 能增强 CFTR 功能、恢复氯离子通道活性，是囊性纤维化研究的重要研究工具。

中文别名

(14S)-8-[3-(2-[DISPIRO[2.0.2.1]庚烷-7-基]乙氧基)-1H-吡唑-1-基]-12,12-二甲基-2Λ6-噻-3,9,11,18,23-五氮杂四环[17.3.1.111,14.05,10]二十四碳-1(22),5,7,9,19(23),20-己烯-2,2,4-三酮

English Alias

Vanzacaftor（VX-121, VX121，13H-17,20-Methano-8,12-nitrilo-12H-pyrido[3,2-d][1,2,6,13]thiatriazacyclooctadecin-5(6H)-one, 2-[3-(2-dispiro[2.0.2.1]hept-7-ylethoxy)-1H-pyrazol-1-yl]-14,15,16,17,18,19-hexahydro-19,19-dimethyl-, 7,7-dioxide, (17S)-） is a novel, orally active cystic fibrosis transmembrane conductance regulator (CFTR) modulator designed to improve CFTR protein processing and trafficking to the cell surface. By enhancing CFTR function and restoring chloride channel activity, vanzacaftor serves as an important research tool in the study of cystic fibrosis.

Category: Biochemicals, Biological Response Modifiers

Purity/Specification: 98% / Kilogram scale （Vanzacaftor Synonyms: 万泽卡托, VX-121, VX121）

CAS: 2374124-49-7

Molecular Formula: C32H39N7O4S

Molecular Weight: 617.76

Density: 1.53 ± 0.1 g/cm³ (Predicted)

Acidity constant (pKa): 2.56 ± 0.40 (Predicted)

Form: Solid

Color: Off-white to light yellow

GHS Hazard Symbol: GHS07

Signal Word: Warning

Hazard Statements: H302-H315-H319-H335

Precautionary Statements: P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

All MICROFLU™ products are intended solely for scientific research and must not be used on humans; we do not supply products or services to individuals. Please adhere to the intended use and refrain from utilizing the products for any other purpose in violation of laws or regulations. Leveraging our extensive experience in compound synthesis, we offer rapid custom synthesis services tailored to your specific research requirements.