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Ethyl 4-fluoro-1H-imidazole-5-carboxylate (CAS: 33235-31-3) - 98% Purity, Kilogram-Scale Supply

2026-07-21 14:15:05
Product Overview

Ethyl 4-fluoro-1H-imidazole-5-carboxylate (also referred to as Ethyl 5-fluoro-1H-imidazole-4-carboxylate, CAS: 33235-31-3) is a highly advanced fluorinated imidazole heterocyclic building block of immense value in modern medicinal chemistry. Because the incorporation of fluorine atoms strategically alters the metabolic stability, lipophilicity, and bioavailability of small-molecule drugs, this compound serves as an indispensable cornerstone molecule in innovative drug design, small-molecule kinase inhibitors, and antiviral/oncology therapeutic pipelines.

Ethyl 4-fluoro-1H-imidazole-5-carboxylate / Ethyl 5-fluoro-1H-imidazole-4-carboxylate

Due to the rigorous reaction conditions required for the fluorination of the imidazole ring, combined with a lengthy synthetic route and immense separation difficulties for positional isomers, stable high-purity kilogram-scale supply is exceptionally rare on the global market. Utilizing our mature directional synthesis and advanced multi-stage crystalline purification technologies, we have successfully broken through these production bottlenecks. We proudly offer 98% high-purity Ethyl 4-fluoro-1H-imidazole-5-carboxylate with stable, kilogram-scale (kg-scale) ready stock to seamlessly accelerate your pharmaceutical profiling and pilot scale-up.
Core Advantages

  • High Polymerization Purity (≥ 98.0%): Refined via advanced purification processes. Unfluorinated raw material residues, defluorinated byproducts, and free inorganic salts are strictly restricted to deliver exceptionally high chemical reactivity and excellent conversion yields in downstream nucleophilic substitution, hydrolysis, or coupling assays.

  • Stable Kilogram-Scale Supply: Supported by a standardized pilot-scale and commercial manufacturing infrastructure with a robust raw material supply chain. We eliminate the market bottleneck of premium, grams-only reagent catalogs, supporting flexible, bulk purchases from hundreds of grams to continuous multi-kilogram batches.

  • Comprehensive Quality Control (QbD): Produced under rigid quality management structures. Every single dispatch is accompanied by a thorough testing package, including a COA (Certificate of Analysis), HPLC (Chemical Purity Analysis), H-NMR, and F-NMR (Fluorine-19 NMR) spectra for complete structural and purity traceability.

  • Airtight & Moisture-Proof Protective Packaging: To counteract the tendency of ester groups and imidazole rings to absorb moisture or degrade under unfavorable storage conditions, the entire packaging cycle is executed in a climate-monitored, ultra-dry facility. Vacuum-sealed pharmaceutical-grade inner bags enclosed in aluminum foil shields guarantee zero quality degradation during long-term storage.

Technical Specifications

  • Chemical Name: Ethyl 4-fluoro-1H-imidazole-5-carboxylate / Ethyl 5-fluoro-1H-imidazole-4-carboxylate

  • CAS Registry Number: 33235-31-3

  • Molecular Formula: C₆H₇FN₂O₂

  • Molecular Weight: 158.13

  • Appearance: White to off-white crystalline powder or solid.

  • Assay / Purity: ≥ 98.0% (HPLC)

  • Storage Conditions: Store at 2-8°C (or in a cool, dry place), tightly sealed, protected from light, and moisture.

  • Standard Packaging: 100g/bottle, 500g/bag, 1kg/aluminum foil bag, 5kg/fluorinated drum (Customized packaging available upon request).

Disclaimer
All chemical products sold by our company are intended solely for laboratory research, export, small-molecule process engineering, or industrial manufacturing R&D. They are not intended for use as food additives, cosmetic raw materials, or clinical drugs in humans.


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